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Other health conditions and metabolism differences also play a role

Avoid Alcohol or Limit It Significantly Alcohol interacts with tirzepatide in multiple ways: it slows gastric emptying (just like the medication does), which can amplify nausea and bloating

They should also be instructed about signs and symptoms that warrant dose adjustment or medical evaluation, including severe gastrointestinal side effects or other unusual symptoms that may indicate adverse reactions, as determined relevant by the prescribing clinician

Some explanations for these strong effects come from mechanistic studies investigating the proportions of the respective GLP-1 and GIP receptor agonistic properties

Most exposures were to liraglutide and semaglutide rather than tirzepatide specifically