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Nicotine was good at making an idea stick: Smoke a cigarette, turn a feeling into a credo

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Regulatory Influence and Trend Timeline Smoking rates in Canada have declined over time, and policy is a major driver of that decline

A tolerance also develops, so that more and more of the drug is needed to get the same effect

Existing literature on the relationship between smoking and specific health outcomes is prolific, including meta-analyses, cohort studies and casecontrol studies analyzing the risk of outcomes such as lung cancer 5,6,7 , chronic obstructive pulmonary disease (COPD) 8,9,10 and ischemic heart disease 11,12,13,14 due to smoking

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