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In general, all manufacturers used higher amounts of glycerol than 1,2-propylene glycol as a humectant, which may act as a precursor for the formation of harmful carbonyl compounds 23

This is the characteristic difference between Chinese Virginia cigarettes (mainly containing flue-cured tobacco) and 3R4F reference cigarettes (blended cigarettes) (Xiong et al., 2010

there are specific grace periods and re-initiation steps if doses are delayed