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The Top US Cigarette Brands in 2026 This section is purely about what Americans are smoking and why those brands dominate

Over time, repeated exposure to nicotine leads to changes in the brains chemistry, resulting in tolerance, dependence, and withdrawal symptoms when tobacco use is discontinued

Acknowledgements The figures were created using Biorender, and the original source can be accessed at: Funding This work was supported by a Grant-in-Aid for Scientific Research from JSPS under Grant Number JP20K16347 (YY

J Toxicol Sci 33(4):415420

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