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When challenged by skeptics to simply stop selling cigarettes now, the company and its paid consultants like Dobbins raise the specter of a huge black market that would quickly emerge, run by rogue elements who take over the industry and circumvent all regulations

The mesolimbic dopamine system is implicated in the reinforcing effects of nicotine

They slowly release flavor over time without the need for chewing

Each of these regulations increases operational complexity and costan expense that gets passed on in the per pack price.Additionally, distribution costs play a role

The regulations also prohibit ads that appeal to youngsters under 18 and ones that encourage non-smokers or non-nicotine users from smoking e-cigarettes

[PubMed] [Google Scholar] 21.McGehee DS, Role LW