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MiR - 195 expression is decreased significantly in the serum samples of ulcerative colitis patients compared to the levels in normal subjects

Specifically, 5 year overall survival is 2040% lower in smokers compared to non-smokers depending on HPV status [6,7,8,9]

doi: 10.1016/j.tibs.2012.04.002

To maintain long-term survival in hepatocytes, hepatitis viruses have lots of ways to destroy the defense strategies of hepatocytes by inducing TP53 mutation and silencing, promoting MDM2 overexpression, accelerating p53 degradation, and stabilizing MDM2

The complexity of p53-mediated metabolic regulation in tumor suppression

The pyrido[b]indole MDM2 inhibitor SP-141 exerts potent therapeutic effects in breast cancer models