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64 The authors review of the literature identified a small number of studies 55-58 that longitudinally assessed lung function in middle-aged subjects who continued to smoke or switched to HTPs, but they were not specifically recruited from a patient population with COPD

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Neurofibrillary tangles (NFTs) are intracellular aggregates of hyperphosphorylated Tau proteins and are hallmarks of AD and other neurodegeneration diseases 113

These studies evaluated several potential factors associated with the reductionsuch as tax hikes, stricter smoking laws, or other nicotine productsand concluded the introduction of HTPs was the most likely explanation for the sharp drop in cigarette sales in those years