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The nitrosamine in tobacco undergoes metabolic activation by cytochrome P450 enzymes, which may lead to the formation of N-nitrosonornicotine, a major carcinogen [65], which further leads to DNA damage and ultimately oral cancer

1 2 Lloyd & Mitchinson Tanya Pollard, "The Pleasures and Perils of Smoking in Early Modern England" in Smoke , p

There are many reasons why we should try to reduce rates of smoking in population for physical health reasons," he said

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The Effects Of Drugs & Antidepressants Zoloft is an antidepressant that affects the reuptake of serotonin

New 4 th generation e-cigarettes like Juul and other pod mods contain high concentrations of nicotine about 5% or 59mg/ml Most of them also use nicotine salts, which can deliver a higher concentration without as much throat irritation as would be the case with the freebase nicotine used in earlier e-cigarettes