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It has been reported that loss-of-function of transporters involved in Zn or Cd efflux into the vacuoles resulted in higher metal translocation to shoots, which was shown for example in Arabidopsis thaliana for AtMTP3 (Metal Tolerance Protein Family) or in Oryza sativa for OsHMA3 (Heavy Metal Transporting P1B-ATPase Family) (Arrivault et al

Nicotine concentration was very close to the declared value, while impurities and contaminants were present in trace quantities

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The southern states, however, continued to rely on slaves for labor in the tobacco and cotton fields