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8,69,70 In the United States, the FDA has authority to authorize marketing claims about reduced risk, which an Institute of Medicine panel concluded should be based on extensive testing of abuse liability, likely health effects, and effects on the whole population

22 The inhalation of vaporized flavorings and chemicals in e-liquids may have neurotoxic effects, leading to neuronal hyperexcitability and aberrant synaptic transmission

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Drivers can also land themselves three penalty points for smoking while driving, if a police officer deems it to be distracting them from driving.