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Urine and blood samples from people using the VELO brand nicotine pouch contained lower levels of several harmful biomarkers compared with samples from cigarette smokers

In addition, avoiding direct comparison between the harms of traditional cigarettes and ENDS is recommended due to existing uncertainties, in particular those related to the high prevalence of dual or multiple product use, the variability of types/generations of ENDS and in their levels of nicotine content, and to a lack of rigourous and standardised comparative studies

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Depressive symptoms can pop up as soon as day one of quitting