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10.1007/s11010-005-2536-z Mol

doi: 10.1124/dmd.107.016170

It has also been shown that aldo-keto reductase family 1 member B1 (AKR1B1) interacts with signal transducer and activator of transcription 3 (STAT3) to up-regulate SLC7A11, which leads to increased Cys 2 uptake in lung cancer cell lines and xenograft mouse models, and further promotes lung cancer cell resistance [80]

Furthermore, research by Kim et al

If your body doesn't have enough cysteine, it will slow the glutathione pathway down, like a bottleneck when several lanes are closed on the highway

Blood J