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In a criminal proceeding, you do not have to prove your innocence, but rather, the prosecution has to prove your guilt

Abbreviations BC: breast cancer TAM: tumor-associated macrophages CCL5: C-C motif chemokine ligand 5 CCR1/3: chemokine receptor 1/3 VCAM-1: vascular cell adhesion molecule 1 E-cig: E-cigarettes CS: cigarette smoking MMPs: matrix metalloproteinases VEGF: vascular endothelial growth factor TNF: tumor necrosis factor EVC: E-cigarette vapor condesate Declarations Acknowledgement None

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In the next step, we plan to use retrospective or cohort studies to determine the causal relationship between smoking and kidney disease, whether CKD progression can be delayed by reducing smoking and more accurately assess the specific kidney damage caused by smoking by adding markers