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All variables satisfy the proportional risk assumption test (Table 2)

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Besides the alterations caused on the differentiated tissues, Tamashiro et al.28 showed that the cigarette smoke has a negative impact on the ciliogenesis process in a dose-dependent fashion to the respiratory epithelium in the maturation and differentiation phases

Its impact spans from impairing cardiovascular health and lymphatic drainage to compromising the immune system, disrupting sleep, and degrading the structural components critical to the skins elasticity and appearance