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Proposed Mechanisms of Action The pathways by which cigarette smoking exerts opposite effects in CD and UC are hard to establish, due to the large number of components in the smoke and the diverse cellular and tissue functions that may be affected, such as the mucosal barrier, gut microbiota, immune system, microvasculature, and others

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The close and prolonged contact of the tobacco with the mouths inner lining, or mucosa, allows the carcinogens to be absorbed

"Nicotine levels in the bloodstream gradually decline, but the vasoconstrictive effects induced by nicotine persist, contributing to sustained elevation in blood pressure," Dr Amuthan explains

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