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Nicotine overdose, which is often associated with feeling nic sick, refers to being exposed to nicotine above the tolerance level of an individual

Physical Withdrawal Symptoms and Management Quitting can make you feel sick, irritable, and have headaches

We recognise that exposure in a lab is different to inhaled smoke over a long time, but it seems reasonable to hypothesise, based on our research and others that stressful conditions imposed by smoking induce responses in microbial cells leading to adaptation to harsh conditions, with the net effect of increasing virulence and/or potential for infection

For case reports, we also used the JBI critical appraisal tools 11