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Apart from acetylcholine, nicotine can also imitate dopamine, the feel-good chemical that is frequently released during rewarding situations

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At the same time, e-cigarettes contain other substances, such as flavor additives, N-nitrosamines, and volatile organic compounds [20] detected in e-cigarettes, as well as metal contamination through heating coils, solders, and wicks, such as cadmium, chromium, lead, nickel, silver, tin, and silicates [20]