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For habitual smokers, its a ritual as familiar as morning coffee

Circ Cardiovasc Qual Outcomes

Pulsed Doppler interrogation of mitral inflow was performed to measure peak early diastolic velocity (E), peak late diastolic velocity (A), their ratio E/A, E wave deceleration time, and isovolumic relaxation time

The clearest, evidence-based advice is: dont start, and if you smoke, quit completely and as soon as you can

Of particular concern with respect to lung cancer are: tobacco-specific nitrosamines (TSNAs, such as 4-(methylnitrosamino)-1-(3-pyridyl)-1-buta-none (NNK) and N-nitrosonornicotine) and polycyclic aromatic hydrocarbons (PAHs)