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Smith says that's where legalization and regulation are helpful in providing some oversight of the ingredients

Brands like Winfield and Marlboro deliver robust flavors (8-12 mg tar) for seasoned smokers, while best cigarettes for new smokers like Esse and Vogue offer milder, low-tar profiles (1-4 mg) for a smoother draw

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Downstream purification is another potential challenge, because of the high cost factor, often equal to that of the biopharming process itself