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Ethical approval The study was approved by the School of Medicine, Dentistry and Biomedical Sciences Ethics Committee at Queens University Belfast on September 21, 2018 (ref
Studies have confirmed that cigarette extracts induce the conversion of macrophages to osteoclasts through the classic RANKL-RANK pathway, upregulate the expression of NFATc1, promote macrophage activation, and induce the expression of the osteoclastogenesis-related proteases TRAP, cathepsin K and MMP-9 (129131)

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The data also suggests the pandemic may have been a trigger for many smokers, including young adults, to think about attempting to quit tobacco

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[1] 604 U.S
