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277,278,279 When dysfunctional mitochondria cannot be cleared in time by mitophagy, damaged mitochondria accumulate, which results in insufficient energy supply as well as overproduced ROS, thereby triggering intense oxidative stress and cellular damage

This is in part of only having animal trials while human trials are still on their means

and Klionsky, D.J

this may potentially result in increased viral load and infectivity within affected patients

Finally, translational success depends on early and sustained collaboration among basic scientists, clinicians, biostatisticians, and regulatory authorities

It provides the building blocks that are necessary to form and maintain strong bones