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Among other protections, the proposed changes would require more frequent training for workers and pesticide handlers, mandate posting of warning signs after applications of certain pesticides, and establish a minimum age of 16 for all pesticide handlers.[120] Pesticide Use in Tobacco Production Tobacco production in the United States involves application of a range of chemicals at different stages in the growth process including chemical fertilizers, pesticides, and growth regulators (growth inhibitors and ripening agents).[121] Several pesticides commonly used during tobacco farming belong to two chemical classes, organophosphates and carbamates, both of which are neurotoxins.[122] The US Government Accountability Office explains that pesticides in these classes, act on the nervous system to prevent the normal flow of nerve impulses to muscles that control both voluntary movement, such as walking, and involuntary movement, such as breathing and heart beat.[123] While pesticides are applied to many crops cultivated in the United States, tobacco workers may be at especially high risk for pesticide exposure given the nature of work