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Chronic irritation causes ciliated and mucus-secreting cells to shift toward cell types that are more resistant to the effects of these toxins

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11 A study in the US found that a minimum tobacco purchase age of 21 lowered the incidence of low birth weight infants by 19 per cent, 44 while another found that Medicaid coverage for NRT, medications and cessation counselling during pregnancy was associated with a small increase in infant gestation