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Additionally, the routine collection of health data for research has now enabled the conduction of bigger studies in actual practice conditions and using the entire population, in contrast with previous cohorts or casecontrol studies mostly conducted in specialised research centres.2 Finally, none of the studies published to date were conducted in Mediterranean populations, where both the incidence/prevalence and the severity of RA are lower than in Northern European and American people.3,4 We therefore took advantage of the existence of routinely collected health data from electronic primary care records in Catalonia (Spain) to study the association between smoking and the development of rheumatoid arthritis in the general population