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Smoking and economic development In Italy, as elsewhere, smoking was initially a mostly male domain and one that spread gradually from the elite to the middle and working classes

Sawicka-Gutaj N, Gutaj P, Sowiski J, et al

As showed by Monticello et al

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These oxidative stress biomarkers exhibit a tendency toward elevated levels within the respiratory system, the primary site of exposure to cigarette smoke [33,34,35]

[34] Evidence suggests smokers are more frequently able to completely quit smoking using tank devices compared to cigalikes, which may be due to their more efficient nicotine delivery