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11 Importantly, structural modifications to GLP-1RAs can prolong their half-life to 5-7 days compared to the 1-5 minute long half-life of endogenous GLP-1

In that case, switching medication classes entirely to tirzepatide may be more productive

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Options include staying at your current dose longer before increasing, temporarily reducing to your previous dose level, implementing more aggressive side effect management strategies, trying anti-nausea medications, or in some cases discontinuing treatment
