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Add to that the base rate squared

In Italy, AIOM estimates around 33,569 smoking-related cancer deaths in men and 9,922 in women each year, with an average reduction in life expectancy of around 12 years for smokers compared to non-smokers

Georgiou CD, Papapostolou I, Grintzalis K (2008) Superoxide radical detection in cells, tissues, organisms (animals, plants, insects, microorganisms) and soils

GBD 2017 Risk Factors Collaborators: Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 19902017: a systematic analysis for the Global Burden of Disease Study 2017

Despite the decline in e-cigarette use between 2019 and 2020, NYTS researchers stressed the need for continued effort to sustain this apparent progress

Of course, the tobacco industry agreed with us