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Follow your plastic surgeons recommendation, which may be to quit three to six weeks before surgery through three to six weeks after (though forever is best)

Some individuals might be more susceptible to this based on their genetics

Directions: Shake well before use

Co-administration of an OCT2 inhibitor, cimetidine (300 mg four times daily), with varenicline (2 mg single dose) to 12 smokers increased the systemic exposure of varenicline by 29% (90% CI: 21.5%, 36.9%) due to a reduction in varenicline renal clearance