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PMID 22913370

crack cocaine is made by converting powdered cocaine into a solid using baking soda or ammonia, which alters its chemical composition and increases its ability to cross the blood-brain barrier rapidly, leading to more intense and immediate effects

Smoking is shown to reduce the effectiveness of blood thinners, which may be prescribed for patients with a heart rhythm disorder or other heart conditions

I was a really good athlete at the time and thought it didn't matter

Nicotine replacement therapy versus control for smoking cessation Cochrane Database Syst Rev 2018;5: CD000146

Thats not to say that there werent any challenges along the way