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Externalising disorders such as conduct disorder, ADHD and oppositional defiant disorder confer risk for: chronic smoking, 45 smoking at an early age, smoking continuation into the 30s, 46 faster progression to daily smoking, nicotine addiction, 47-49 and may be associated with greater tobacco consumption following uptake

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One widely used commercial assay, the HerpeSelect HSV-2 EIA, has an overall specificity of about 57 percent, dropping to roughly 40 percent for borderline-positive index values in the 1.1 to 2.9 range, per real-world data cited in the CDC STI Treatment Guidelines

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