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The original GLP-1 receptor agonist was exenatide, which was first synthesised in 1996

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Probably, it is the result of translocation of bacterial components, particularly LPS, into the portal vein and thus to the liver, resulting in liver inflammation and injury [47]

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Eating less can also play a role

In addition, they are being explored for their implications in reducing the risk of cardiovascular disease and cancer, and treating high blood pressure, kidney disease, autoimmune diseases and other conditions such as sleep apnea, fatty liver disease, Alzheimers disease, smoking cessation and substance use disorder