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Traditional cigarettes burn tobacco at temperatures over 800C, releasing more harmful constituents, while Heated Tobacco Products operate at lower temperatures, resulting in reduced exposure to toxicants

Men who smoked 20 cigs a daygenerally a packhad more than double the chances of heart disease than nonsmokers

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However, smoking prevalence and associated ill health continued to rise in the developed world in the first three decades following Richard Doll's discovery, with governments sometimes reluctant to curtail a habit seen as popular as a result and increasingly organised disinformation efforts by the tobacco industry and their proxies

The dose-response relationship is consistent: more smoking, faster progression