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Substances that have been found in e-cigarettes include: hydrocarbon a chemical used to deliver the nicotine in vapes, which can cause inflammation or pneumonitis acrolein a substance linked to several lung-related disorders formaldehyde an organic compound linked to lung damage and cancer diacetyl a flavouring chemical that has been linked to serious lung disease heavy metals such as nickel, tin and lead propylene glycol and vegetable glycerine aerosols that can induce heart rhythm issues Some vapes for sale in Ireland have also been found to contain higher-than-advertised levels of nicotine

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According to the 2014 Surgeon Generals Report, there is sufficient evidence to infer that cigarette smoke exposure compromises the immune system and immune homeostatis, which increases risk for several disorders, including pulmonary infection

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