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Treatment for nicotine allergy usually involves avoiding exposure to nicotine and using medications to manage symptoms

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If a person feels their medication is not working properly, they should consult a doctor and not increase the dose themselves.

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Another ligand for RAGE is the nuclear protein high-mobility group box-1 (HMGB1), which is normally buried deep within the nucleus and can be released into the extracellular space by passive diffusion from necrotic cells or by active secretion from activated macrophages/monocytes

Nicotine is highly addictive, and whether vaping of e-cigarettes will perpetuate nicotine use or act as a gateway to smoking is as yet unknown