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Because the difference between [e-cigarettes] and varenicline at one year is not statistically significant (just misses), the study cannot conclude that varenicline is better, though it hints that [a] larger study might find that, Rigotti explained

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[220] A 2013 study by The British Journal of Psychiatry has found that smokers who successfully quit feel less anxious afterward, with the effect being greater among those who had mood and anxiety disorders than those who smoked for pleasure

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