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Methotrexate Methotrexate is a widely used drug to treat cancer and autoimmune diseases such as rheumatoid arthritis and psoriasis
C.StrbianD.YassiN.PutaalaJ.TatlisumakT.et al (2016)
10.1016/j.tips.2017.02.005 10 AnsariM
The application of oxamate by inhibiting lactate production can convert tumor-infiltrating lymphocyte and CAR-T cell phenotypes to a more potent state, maximizing tumor-killing effects and improving survival rates in GBM mouse models when combined with CAR-T [169]
Upon HIF-1 activation, key glycolytic enzymes are upregulated, boosting cellular energy production (Thind et al., 2023)
doi:10.1183/09031936.97.10071535 68
