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Adult male rat hippocampus synthesizes estradiol from pregnenolone by cytochromes P45017alpha and P450 aromatase localized in neurons

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This pattern suggests that phytocannabinoids might selectively affect gonadal androgen synthesis without altering adrenal or peripheral pathways, possibly via direct effects on the testes, or disruption of the hypothalamicpituitarygonadal (HPG) axis function
