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The efficacy and safety of varenicline was evaluated in a randomized, double-blind, placebo-controlled study of 312 patients aged 12 to 19 years, who smoked an average of at least 5 cigarettes per day during the 30 days prior to recruitment, had a score of at least 4 on the Fagerstrom Test for Nicotine Dependence scale, and at least one previous failed quit attempt

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Cigarette smoke has toxins that damage the lining of the blood vessels

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National Institute on Drug Abuse - Is nicotine addictive? Warfighter Wellness - The Cost of Cigarette Use Warfighter Wellness - Thinking About Quitting Tobacco Warfighter Wellness - Tobacco You Can Quit 2 - Ditch Tobacco for a Healthier Diet You Can Quit 2 - Questions About Electronic Cigarettes You Can Quit 2 - Tobacco-Free Products

Role of smoking in global and regional cancer epidemiology: current patterns and data needs