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Much of this decline is attributed to tobacco policy efforts, including price increases, smoke-free air laws, and youth access restrictions, as well as mass media public education and prevention campaigns

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An assay measuring the abundance of H2AX in human bronchial epithelial cells can, therefore, be used to evaluate whether the extent of DNA double-strand breaks caused by the cMRTP aerosol is lower than that caused by cigarette smoke [47, 48]