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J Neurosci 36:1136211373 Feldman HM, Yeatman JD, Lee ES, Barde LH, Gaman-Bean S (2010) Diffusion tensor imaging: a review for pediatric researchers and clinicians

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Several studies have shown that endothelial function assessed by biomarkers for endothelial function including circulating levels of nitrate/nitrite, NO, von Willebrand factor (vWF), cellular adhesion molecules, vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1), endothelial progenitor cells (EPCs) and endothelial microparticles (EMPs), endothelin-1 and activity of endothelial NOS (eNOS) other than physiological assessment for endothelial function was impaired in smokers

However, in the 1760s, Washington began to seek alternatives to growing primarily tobacco as he embraced practices in new husbandry