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Pre-treatment with a GLP1 receptor-blocking antibody neutralised the CNO-dependent improvement in glucose tolerance but did not affect the reduction in food intake, and an independent group of animals pair-fed to the CNO-treatment group demonstrated attenuated weight loss

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Semaglutide or Tirzepatide Weight Management with Consultation

Three months after stopping a GLP-1, 40% of patients had further improved their HbA1c compared to when they discontinued the GLP-1, 48% kept some of their improvement, and just 12% had a worse HbA1c compared to their pre-GLP-1 level.

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Even the biggest future blockbuster drugs can be prematurely abandoned.