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The effect was dose-dependent: the more someone used per week, the worse their vascular function. Worryingly, even relatively small doses of 2.5mg multiple times a week seemed to have a harmful effect

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Furthermore, sales of the higher nicotine concentration products rose more dramatically than lower nicotine concentration products

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CONCLUSIONS The current findings confirmed increased smoking-related death risk among former and current smokers, and that previously reported lower risks were due to a lack of details for smoking behaviors, such as smoking amount and duration