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This loss of DA causes a deregulation in the basal ganglia circuitries that leads to the appearance of motor symptoms such as bradykinesia, resting tremor, rigidity, and postural instability as well as non-motor symptoms such as sleep disturbances, depression, and cognitive deficits (Rodriguez-Oroz et al., 2009)

Particularly important for those on acid-blocking medications, metformin, vegetarians, or patients with gastritis

Discussion In this randomized, blinded clinical trial of vitamin B-12 supplementation during pregnancy and early lactation, we found that urban south Indian women responded with higher plasma and breast milk concentrations of vitamin B-12

(John Wiley & Sons, 2022)

In addition, elevated methylation of histone H3 lysine 27 (H3K27me3) by EZH2 further stabilizes this reversible quiescent state by repressing lineage-specific gene expression programs (Marso et al., 2022)

Perez KM, Laughon M