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One fanciful story described how Sir Walter Raleghs servant, seeing him smoking a pipe for the first time, threw a bucket of water on him, assuming that he was on fire

The primary notes I get are tobacco, whiskey, cinnamon, and spice notes

Henderson of the law office Cook & Henderson to executives of The Tobacco Institute, September 12, 1979.This 2-page summary by Paul J

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This seems to be the method most likely to yield exposures equivalent to those for which relative risks have been estimated, as well as allowing estimates specific to the UK (which controls from casecontrol studies cannot)

Science 326: 544550