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In particular, further investigation is needed to determine if reliance on pack-years is appropriate to guide healthcare policy or for enrollment in clinical trials of COPD, or for other uses, all of which typically rely on a minimum of a 10 pack-year history

HPLC-NMR with severe column overloading: Fast-track metabolite identification in urine and bile samples from rat and dog treated with [14C]-ZD6126

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In further sub-group analyses, the association was significant in the studies that used the standardized ISAAC protocol (RR = 1.50, 95% CI 1.351.66), but not those that used their own protocol (RR = 0.96, 95% CI 0.881.08)

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