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Simulation models are useful and can often be the most reliable sources for estimating long-term effects of interventions, but the projections are only as valid as their underlying assumptions and their input and transitional probability parameters, which are generally based on available data and sensitivity analysis (see Appendix 15.1 in USDHHS 2014)

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Ethics declarations Ethics approval and consent to participate The trial was approved by the Institute Review Board of School of Public Health, Sun Yat-sen University (Ref

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