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In the past decade, there has also been a growing discussion on capping the nicotine in cigarettes to a non-addicting level: 0.4 mg/g or less, a 95% reduction compared to the 10-15 mg/g found in most cigarettes

While CBD is generally considered safer in controlled doses, THC ingestion can lead to severe side effects

Some toxic effects induced by tobacco smoke, result from direct genetic or epigenetic effects resulting in altered gene functions (for example, cell cycle, DNA repair, and tumor suppressor genes)

Sean Marsee, pictured here, started using oral tobacco at age 12

Waterpipe smoking has also been linked to an increased risk of coronary artery disease, an increased incidence of ST-elevation myocardial infarction (STEMI) compared to non-ST-elevation myocardial infarction (NSTEMI), an increased risk of re-infarction, and mortality 12,13
