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Direct detection methods involve identifying MPs directly in biological samples such as plasma, serum, urine, saliva, or whole blood, using advanced analytical techniques

More information Here is the link to Generalized urticaria following the use of e-cigarette: a case reported during a switching trial:

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Exp Lung Res 31:318 Alexander DJ, Collins CJ, Coombs DW, Gilkison IS, Hardy CJ, Healey G, Karantabias G, Johnson N, Karlsson A, Kilgour JD, McDonald P (2008) Association of inhalation toxicologists (AIT) working party recommendation for standard delivered dose calculation and expression in non-clinical aerosol inhalation toxicology studies with pharmaceuticals

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