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This version simulated movements of females without a predetermined endpoint (whereas the first set of maps above provided the simulated bears with these endpoints in adjacent populations)

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Notably, PRPS1, which is upregulated in CR hi NSCLC tumors, couples the PPP with de novo purine nucleotide synthesis, thereby directly linking the PPP with the purine nucleotide bias seen in these tumors

For detail on the impact in individual states, see Appendix G for the state-by-state Who Pays