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So this piece of empirical data must be the key for understanding what is really happening

doi:10.1016/j.tics.2006.01.011 30

E-cigarettes, also known as vapes, include any product containing or delivering nicotine or any other substance intended for human consumption that can be used for the purpose of inhaling vapor or aerosol from the product

What's left of the former

The activation of each receptor has specific G-protein dependent intracellular effects

Moreover, companies like Philip Morris are all too happy to dismiss smoking as old news so they can continue down their old path
